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AICAR phosphate
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy. It serves as an adenosine analog, regulating glucose and lipid metabolism, and inhibiting the production of pro-inflammatory cytokines and iNOS.
Catalog No. T14149Cas No. 681006-28-0
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AICAR phosphate
Catalog No. T14149Cas No. 681006-28-0
AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy. It serves as an adenosine analog, regulating glucose and lipid metabolism, and inhibiting the production of pro-inflammatory cytokines and iNOS.
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $49 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | AICAR phosphate (Acadesine phosphate) is an AMPK activator and inhibitor of autophagy, YAP, and mitophagy. It serves as an adenosine analog, regulating glucose and lipid metabolism, and inhibiting the production of pro-inflammatory cytokines and iNOS. |
| In vitro | HepG2 cells were treated with different concentrations of AICAR phosphate (0.1-1.0 mM) for 12, 24, and 48 hours, respectively. The final results demonstrated that AICAR phosphate reduced the expression of the insulin receptor protein[1]. |
| In vivo | Male 5-week-old ZDF rats were either subcutaneously injected with a single dose of AICAR phosphate (0.5 mg/g) or subjected to a single bout of treadmill running. The results showed that compared to untreated control ZDF rats, both the exercise group and the rats receiving AICAR phosphate injection exhibited significantly increased AMPK-α2 activity in the white gastrocnemius muscle[2]. |
| Alias | AICA Riboside phosphate, Acadesine phosphate |
| Formula | C9H14N4O5.xH3O4P |
| Cas No. | 681006-28-0 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O: 80 mg/mL (224.57 mM), Sonication is recommended. DMSO: 75 mg/mL (210.54 mM) |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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